A potential catalytic site revealed by the 1.7-angstroms crystal structure of the amino-terminal signalling domain of Sonic hedgehog
Article Abstract:
The 1.7-Angstroms crystal structure of the amino-terminal residue of murine Sonic hedgehog (Shh-N) signaling protein contains the catalytic site for cell-to-cell signalling. In this structure, a residue with tetrahedral zinc is present which is structurally similar to the zinc coordination positions of zinc hydrolases. The Shh-N hydrolyzes a peptide substrate and the Shh-N hydrolase activates a receptor by proteolysis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A new grammar for drug discovery
Article Abstract:
The identification of a target for a new drug is considered, which is the choice of a gene product of clinical relevance. It is suggested that a new kind of grammar is required that would apply right from the discovery of a drug target, to its testing in animal models and finally to the treatment of patients and such a kind of grammar of drug discovery should be embedded in biological systems.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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The genomic cosmos
Article Abstract:
The role and interpretation of genetics screens is discussed. The use of large-scale screens and screens after mutation cloning is examined, and the prospects for future screens are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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