A radical vascular connection

Article Abstract:

A new study has discovered another disorder related to endothelium-derived relaxing factor. Thomas et. al. found a possible connection between endothelial dysfunction and beta-amyloid peptide, which has been linked to Alzheimer's disease and age-associated neurodegeneration. Super-oxide dismutase (SOD) was found to prevent such damage by beta-amyloid. A number of caveats about the results exist, however. One is that O2(super -) production is only inferred and not measured. Another is the necessity f pretreatment with SOD to protect against the toxic effects of beta-amyloid, which has several implications. Third is the abnormal severity of beta-amyloid-mediated endothelial damage.

Alzheimer's disease, Nervous system, Nerve degeneration, Superoxide dismutase, Endothelium-derived relaxing factors

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Blood traffic control

Article Abstract:

The arterial blood flow, which means the trafficking in the oxygenated red blood cells, is governed by local modulation of the diameter of small resistance vessels that suggest a role for the vasodilator nitric oxide (NO). The blood flow is precisely matched to the metabolic requirements by the help nitric oxide and haemoglobin.

Science & research, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Industrial Gas Manufacturing, Industrial gases, Nitric Oxide, Vasodilators, Vasodilator agents, Microcirculation, properties

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A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans

Article Abstract:

Research is presented concerning the mechanisms used by the cells of Saccharomyces cerevisiae, mouse macrophages and Escherichia coli to protect themselves from the S-nitrosothiols used for defence purposes.

Escherichia coli, Enzymes, Macrophages, Letter to the Editor, Saccharomyces cerevisiae

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