A role for glucagon-like peptide-1 in the central regulation of feeding
Article Abstract:
The glucagon-like peptide-1 amide (GLP-1) is responsible for the regulation of feeding in rats. Intracerebroventricular (ICV) injection of GLP-1 receptor antagonist, extendin, inhibits the action of GLP-1. Exendin has no effect on fast-induced feeding, but it increases the food intake as well as the action of appetite stimulant neuropeptide Y in satiated rats. An ICV injection of GLP-1 stimulates the induction of c-fos in the paraventricular nucleus of the hypothalamus. The induction of c-fos gives an indication of neuronal activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Sticky fingers grab a lipid
Article Abstract:
The early endosomal autoantigen EEA1, which is associated with early endosomes in mammalian cells, binds to phosphatidylinositol-3-phosphate (PtdIns(3)P) through its FYVE domain. It has been established that both wortmannin and mutations in the FYVE domain that disrupt binding to PtdIns(3)P lead to dissociation and redistribution of EEA1 to the cytosol. Research also indicates that Vps27p, Fab1p and Vac1p bind PtdIns(3)P in vitro. The need for PtdIns(3)P can be bypassed if there is an excess of membrane-bound Rab5-GTP.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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An anorexic lipid mediator regulated by feeding
Article Abstract:
Research is presented concerning the reduction which occurred in oleylethanolamide biosynthesis in the small intestine of rats deprived of food. The behaviourally selective nature of the anorexic effect is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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