A siRNA-based microbicide protects mice form lethal herpes simplex virus 2 infection
Article Abstract:
Vaginal instillation of small interfering RNAs (siRNA) targeting HSV-2 protects mice from lethal infection. siRNAs mixed with lipid are efficiently taken up by epithelial and lamina propria cells and silence gene expression in the mouse vagina and ectocervix for at least nine days and these results suggest that siRNAs are attractive candidates for the active component of a microbicide designed to prevent viral infection or transmission.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Dissecting self-renewal in stem cells with RNA interference
Article Abstract:
Genetic mechanisms controlling self-regulation in mouse embryonic stem (ES) cells are identified using an integrated functional genomics approach. Short hairpin RNA (shRNA) loss-of-function techniques are used to downregulate a set of gene products whose expression patterns suggest self-renewal regulatory functions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Stealth RNAi directs differentiation of mouse embryonal carcinoma cells and embryonic stem cells
Article Abstract:
The power of RNAi to silence genes responsible for key developmental pathways and to direct differentiation of stem cells is demonstrated. Stealth RNAi second-generation RNAi compounds overcome the limitations of traditional small interfering RNAs by combining increased stability and specificity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Path to approval proves rocky for copycat biodrugs. Copycat consolidation. The chips are down
- Abstracts: A field-based evaluation of a presence-absence protocol for monitoring ecoregional-scale biodiversity. Transferring research to endangered species management
- Abstracts: An adapted method for sampling earthworms at night in wildlife studies. Individual activity rates in wintering Eurasian woodcocks: Starvation versus predation risk trade-off?
- Abstracts: Medicare compels heart patients to enlist in follow-up research
- Abstracts: 'No entry' signal in ant foraging. Trail geometry gives polarity to ant foraging networks. Longevity and detection of persistent foraging trails in Pharaoh's ants, Monomorium pharaonis (L.)