A structural role for hormone in the thyroid hormone receptor
Article Abstract:
The binding of ligand to the thyroid hormone (TH) receptor ligand-binding domain (LBD) appears to play a structural role in the mechanism of active conformation of the receptor. The ligand is buried inside the LBD, forming a part of the hydrophobic core, according to the rat alpha(sub 1) TH LBD's crystal structure when bound with a TH agonist. The hydrophobic core forms a part of the hormone binding region and the carboxy-terminal activation region forms an amphipathic helix.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Article Abstract:
The administration of bile acids (BAs) to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin. The results show that the circadian variation in serum BA levels might be a biurnal hormonal signal reflecting food intake and one of the major factors in diet-induced homeogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Bile acids heat things up
Article Abstract:
The role of bile acids in regulating fat that might be exploited pharmacologically to treat obesity is discussed. Bile acids plays an important role in regulating thyroid hormone signaling and energy homeostasis and they also stimulate production of active thyroid hormone in fat cells, which mitigate diet-induced obesity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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