A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans
Article Abstract:
A Caenorhabditis elegans locus, lev-10, required for postsynaptic aggregation of ionotropic acetylcholine receptors (AChRs) is identified. The lev-10 mutants were identified on the basis of weak resistance to the anthelminthic drug levamisole, a nematode-specific cholinergic agonist that activates AChRs present at neuromuscular junctions (NMJs) resulting in muscle hypercontraction and death at high concentrations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
SNF-6 is an acetylcholine transporter interacting with the dystrophin complex in Caenorhabditis elegans
Article Abstract:
The interaction between snf-6, which is an acetylcholine transporter and the dystrophin complex in Caenorhabditis elegans, is studied. Results indicate that in Caenorhabtis elegans, the muscle degeneration resulting from disruption of the dystrophin-glycoprotein complex (DGC) could be caused due to the loss of snf-6-mediated acetylcholine uptake and prolonged muscle excitation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
Article Abstract:
Research is presented concerning the formation of the SNARE complex, which consists of the proteins SNAP-25, synaptobrevin and syntaxin, as the priming stage of the exocytosis the synaptic vesicle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Mutant mice live longer. Correct Hox gene expression established independently of position in Caenorhabditis elegans
- Abstracts: The mahogany protein is a receptor involved in suppression of obesity. The missing link with obesity?
- Abstracts: Hunt for the magnetoreceptor. Brainless eyes. Ant odometry in the third dimension
- Abstracts: Academy backs science in Endangered Species Act. Lost Mars mission thrusts Russian space science further into crisis
- Abstracts: Transgenerational induction of defences in animals and plants. The impact of ultraviolet radiation on the vertical distribution of zooplankton of the genus Daphnia