Activity-dependent dynamics and sequestration of proteasomes in dendritic spines
Article Abstract:
The N-methyl-D-aspartate (NMDA) receptor-dependent redistribution of proteasomes from dendritic shafts to synaptic spines upon synaptic stimulation is reported providing a mechanism for local protein degradation. Proteasome sequestration is persistent, reflecting an association with actin-based cytoskeleton, and it is indicated that synaptic activity can promote the recruitment and sequestration of proteasomes to locally remodel the protein composition of synapses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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ER-phagosme fusion defines an MHC class 1 cross-presentation compartment in dendritic cells
Article Abstract:
The mechanism of cross presentation in which peptides derived from phagocytosed antigens presented to CD8+ T lymphocytes on major histocompatibility complex (MHC) class I molecules are described. Phagosome fusion with endoplasmic reticulum (ER) and furthur reaction is explained.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin
Article Abstract:
Anthrax is considered to be dangerous as it possess an agent of biological terrorism. Anthrax lethal toxin (LT) is a critical virulence factor of B. anthracis, which occurs as a complex of protective antigen and lethal factor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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