Adenylyl cyclases and the interaction between calcium and cAMP signalling
Article Abstract:
Adenylyl cyclase, a second messenger generator in cellular signal transduction, is regulated by cytosolic calcium ions. An inhibition of adenylyl cyclase by Ca2+ results in an increase of cellular cyclic AMP levels. In contrast to the earlier view of a prominent role of G-protein alpha-subunits, findings suggest a predominant role of protein kinase C, Ca2+ and beta gamma subunits of G proteins in the regulation of adenylyl cyclases. Adenylyl cyclases are huge polypeptides similar to transporter molecules.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Spanning binding sites on allosteric proteins with polymer-linked ligand dimers
Article Abstract:
Allosteric effector proteins such as cyclic-nucleotide-gated (CNG) channels mediate the activities of cyclic nucleotides. Polymer-linked ligand dimers (PLDs) were synthesized by a reaction of a sulphydryl derivative of cGMP with a vinylsulphone-derivatized polyethyelene glycol (PEG). PLDs were applied to excised patches containing rat olfactory or bovine rod photoreceptor CNG channels. Some PLDs showed apparent affinities that were higher than cGMP.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Single cyclic nucleotide-gated channels locked in different ligand-bound states
Article Abstract:
An innovative technique makes it possible to analyse the workings of an allosteric membrane protein, the cyclic nucleotide-gated ion channel. The experiment shows the process of channel activation by cyclic GMP and also examines the conformational changes in proteins caused by the binding of small molecules. Details of the study are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: An African origin for the intimate association between humans and Helicobacter pylori. First insights into the biodiversity and biogeography of the Southern Ocean deep sea
- Abstracts: Effects of NF-kappa-B1/p105 processing of the interaction between the HTLV-1 transactivator Tax and the proteasome