Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer
Article Abstract:
It has been established that, in neurons, the constitutive activity of the metabotropic glutamate receptors mGluR1a and mGluR5 is determined by Homer proteins, which bind directly to the carboxy-terminal intracellular domains of the receptors. This work is consistent with earlier work showing that H1a does not have an impact on membrane localization of mGluR1a and mGluR5.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Functional coupling between ryanodine receptors and L-type calcium channels in neurons
Article Abstract:
The stimulation of the type-1 metabotropic glutamate receptor (mGluR1) induces a tight functional coupling between ryanodine receptors and L-type calcium channels in neurons. The stimulation of mGluR1 facilitates L-type calcium channel activity. The stimulation of channel activity is independent of inositol 1,4,5-trisphosphate and typical protein kinases, and is mimicked by caffeine. Ryanodine inhibits both the mGluR1 and caffeine-induced increase in L-type calcium channels in neurons.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Homer: a protein that selectively binds metabotropic glutamate receptors
Article Abstract:
The PDZ proteins are a family of proteins that contain modular PDZ domains and interact with synaptic ionotropic glutamate receptors and ion channels. A new dendritic protein called Homer is described, which seems to be representative of a novel family. Unlike members of the PDZ family, Homer has a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors. The gene's expression is also regulated as an immediate early gene and is dynamically responsive to physiological synaptic activity, particularly during cortical development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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