Artemisinins target the SERCA of Plasmodium falciparum
Article Abstract:
Research points out that artemisinins inhibit the SERCA orthologue PfATP6 of Plasmodium falciparum in oocytes of Xenopus and that chelation of iron by desferrioxamine abolishes the antiparasitic activity of artemisinins resulting in the weakening of the inhibition of PfATP6. Together, the data suggest that artemisinins act by inhibiting PfATP6 following iron activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Analyse this
Article Abstract:
In industry, it is essential for monitoring the safety of drugs and, in basic science, it is necessary for drawing casual relationships conclusively, for instance, between multiple genes and a single disease. Today, biostatistics offer lucrative salaries and a variety of projects that go beyond simple 'number crunching'.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Escape from inhibition
Article Abstract:
Mutations in the Abl protein have been the cause of some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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