Asymmetric segregation of the homeodomain protein Prospero during Drosophila development
Article Abstract:
A study conducted on the development of central nervous system of Drosophila shows that the Prospero protein, formed in neuroblasts, is passed on only to the ganglion mother cells and not to the daughter neuroblast. The correct gene expression of ganglion mother cells requires the transcription factor Prospero. The asymmetric segregation of transcription factors is an intrinsic mechanism to establish asymmetry in gene expression between sibling cells. The asymmetric movement of Prospero requires the domain between amino acid 871 and 902 of the carboxy-terminal.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Making one cell from two
Article Abstract:
Meltrin-alpha, meltrin-beta and meltrin-gamma are the genes present in the muscle cells that encode proteins whose sequence is homologous to fertilin proteins. Meltrin-alpha is involved in the fusion of myoblasts during the formation of multinucleate muscle fibres. The protein appears in the skeletal muscles and bones when fusion starts. When transfected into cells of the C2 mouse muscle cell line, the full-length version of meltrin-alpha slows fusion, whereas fusion is accelerated by a shortened version where the metalloprotease domain is absent.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A metalloprotease-disintegrin participating in myoblast fusion
Article Abstract:
The fusion of myoblasts to form myotubes requires the action of the meltrin-alpha gene, a member of the metalloproteinase/disintegrin protein family. Inhibition of meltrin-alpha gene expression by antisense DNA, prevents the formation of myotubes in C2 cells. Myoblast fusion also requires proteolysis of the meltrin-alpha protein. The full length protein inhibits fusion while a truncated protein stimulates it. The protein is similar in structure to fertilin which is involved in the fusion of the sperm to the egg.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
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