Beta-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Article Abstract:
Loss of functional adenomatous polyposis coli (APC) protein leads to an accumulation of Beta-catenin. Mutant forms of Beta-catenin have been found in colon cancers, retaining wild-type APC genes. Beta-catenin is shown to active transcription from the cyclin D1 promoter and promoter sequences, linked to consensus TCF/LEF-binding sites, are required for activation. Oncoprotein p21ras leads to further transcription of cyclin D1, and expression of a dominant-negative form of TCF in colon-cancer cells restricts expression of cyclin D1, without affecting cyclin D2, cyclin E or cyclin-dependent kinases 2, 4 or 6 expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Teaming up to restrain cancer
Article Abstract:
Tumour-suppressor genes act as buffers against tumour progression as long as they are fully active. P53 is a well known tumour-suppressor gene, and is the most frequent target for genetic alterations in cancer. Garkavtsev and colleagues have reported that p53 does not restrain cancer on its own, but requires a protein encoded by ING1, another tumour-suppressor gene. The link between the two proteins p33ING1 and p53 were considered more closely and it was found that each requires the other to exert its inhibitory effects.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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