Injected cytochrome c induces apoptosis
Article Abstract:
Apoptosis is activated by the injection into cells of cytochrome c, an important mitochondrial protein. It was established that this effect is caspase-dependent. There are a number of possible explanations for the fact that cells overexpressing Bcl-2 are protected from the apoptosis induced by injecting cytochrome c. It is possible that, when overexpressed, Bcl-2 may act as a transporter for cytochrome c back into mitochondria.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Control of apoptosis and mitotic spindle checkpoint by survivin
Article Abstract:
Survivin, a new inhibitor of apoptosis (IAP) protein is found to be expressed in the C2/M stage of the cell cycle in a cycle-regulated way. Survivin associates with microtubules at the start of mitosis and disruption of the survivn-microtubule interaction leads to loss of the inhibitor's anti-apoptosis function. This suggests that it may counteract the default induction of apoptosis in G2/M phase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
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