Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
Article Abstract:
It has been established that the type III TGF-beta receptor, betaglycan, can operate as an inhibin coreceptor with ActRII, a type II receptor serine kinase. Betaglycan binds inhibin with high affinity and boosts binding in cells coexpressing ActRII and betaglycan. The data produced by this research are consistent with a model in which the inhibin/betaglycan complex competes with activin for access to ActRII and thus stops the formation of the activin/ActRII complex needed for recruitment of the type I receptor serine kinase ALK4 and initiation of the activin-signalling cascade.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14
Article Abstract:
It has been possible to isolate a human G-protein-coupled receptor that shows the pharmacological characteristics of a urotensin-II receptor. Cells expressing this receptor show high-affinity binding sites for, and respond to, both goby and human U-II. It was found that U-II lacks systemic pressor activity in anaesthetized rats upon intravenous administration. However, human U-II caused contraction in all non-human primate arterial vessels studied, including both elastic and muscular arteries.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor
Article Abstract:
Urocortin is a mammalian neuropeptide which has sequential identity with fish urotensin I and corticotropin-releasing factor (CRF). The transfected type-1 CRF receptors are activated on coordination with urocortin. Urocortin potentiates the secretion of adrenocorticotropic hormone both in vivo and in vitro. Compared to CRF, urocortin effectively binds to and activates type-2 CRF receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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