Taxol found on tubulin
Article Abstract:
The use of technically advanced electron crystallography enabled the production of new images of taxol-bound tubulin sheets which are comparable to images obtained via X-ray crystallography or multidimensional nuclear magnetic resonance imaging. Electron crystallography will enhance scientists' capacity to obtain images of the binding of drug molecules to their target proteins. One potential application is in studies of the way potential antitumor drugs bind to tubulin, which has a key role in the movements of chromosomes during mitosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Structural polymorphism of bacterial adhesion pili
Article Abstract:
Minute bacterial adhesion pili are formed by the tight winding of very thin structures. The pili are used for binding and maintaining the attachment of bacteria and target cells. The pili are capable of unraveling without undergoing depolymerization as they produce thin and long, extended structures to maintain their attachment to the lost cells. This enables the bacteria with pili to remain in the body of the host, while other bacteria are removed during the flow of urine.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Cancer drugs better than taxol?
Article Abstract:
Scientists led by K.C. Nicolaou are synthesizing epothilone compounds for potential applications in cancer chemotherapy. These cytotoxic compounds, which are produced from a strain of the 'Sorangium cellulosum,' are expected to provide better cancer-treating properties compared with taxol. Epothilones work by promoting the creation of stable bundles of microtubules and preventing microtubule disassembly.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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