Biochemical evidence that patched is the hedgehog receptor

Article Abstract:

Evidence from binding studies, utilizing the labelled Sonic hedgehog (Shh) protein, reveals that patched (ptc) gene encodes the signals from the Hedgehog receptor. The human recombinant amino-terminal fragment of Shh protein labeled with iodine binds ptc mRNA-infused oocytes. However, it fails to bind the control-cell surface encoded mRNA-infused oocytes or the oocytes without infusion. The ptc gene protein binds to the smoothened gene encoded protein and inhibits its activity.

Research, Genetic aspects, Proteins, Developmental biology, Cell receptors, Binding sites (Biochemistry), Active sites (Biochemistry)

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Lunatic fringe is an essential mediator of somite segmentation and patterning

Article Abstract:

The essential requirements for the lunatic fringe gene in murine development was determined through the generation of a targeted mutation with the entire first coding exon removed. Southern blot analysis was used to confirm correct targeting. Lunatic fringe mRNA was not seen in homozygous mutants, indicting that the allele is a null mutation. Homozygous mutant animals showed reduced viability at birth and prior to weaning, and surviving animals were obviously phenotype.

Observations, Gene expression, Somite, Somites (Embryology)

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Clocks and Hox

Article Abstract:

New research indicates a causal link between the processes involved in the formation of vertebrate segments. There is now strong evidence of a connection between activation of Hox genes and segmentation. It appears that, when Hox genes are activated by the clock in the presomitic mesoderm, they maintain their expression boundaries in somites and their derivatives.

Vertebrates, Animal anatomy

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