Boning up on Hedehog's movements
Article Abstract:
The Hedgehog (Hh) group of secreted proteins act as intercellular signals in many processes. In Drosphila melanogaster, the fruitfly, six genes are implicated in transduction of the Hh signal. Human homologues of three of them are identified as oncogenes or tumour suppressors in the nervous system and the skin. Bellaiche and colleagues have discovered a seventh gene, named tout-velu (ttv), which is shown to mediate movement of Hh over responding cells in the wing of Drosophila. ttv is also homologous to EXT-1 and EXT2 which are genes linked to benign bone tumours in humans.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
smoothened encodes a receptor-like serpentine protein required for hedgehog signalling
Article Abstract:
The smoothened (smo) segment polarity gene of Drosophila is needed for cellular response to hedgehog signalling during development of the embryonic segments and imaginal discs. The smo gene is an open reading frame of 1024 amino acid that encodes a protein containing seven putative transmembrane domains which is typical of G-protein-coupled receptors. This indicates that the Smoothened protein may have a role in signalling and function as a receptor for the Hedgehog ligand.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Induction of a specific muscle cell type by a hedgehog-like protein in zebrafish
Article Abstract:
Echidna hedgehog is expressed in the notochord and protects the muscle pioneer cell differentiation in zebrafish mutants lacking the notochord. The patterning activities of the notochord are regulated by the protein, Sonic hedgehog, in vivo. Combined expression of ectopic echidna hedgehog and sonic hedgehog activates supernumary muscle pioneers in wild-type embryos. This suggests that both signals act in a sequential manner in the patterning of developing somites.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Glycine-receptor activation is required for receptor clustering in spinal neurons. SNAP-mediated protein-protein interactions essential for neurotransmitter release
- Abstracts: A growing coactivator network. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha
- Abstracts: From managing a deer herd to moving a mountain - one pilgrim's progress. A serum pregnancy test with a specific radioimmunoassay for moose and elk pregnancy-specific protein B
- Abstracts: Analysis of fusion gene and encoded photopigment of colour-blind humans. Ecological importance of trichromatic vision to primates
- Abstracts: Kings, tree rings and the old world. Language-tree divergence times support the anatolian theory of Indo-European origin