CD1c-mediated T-cell recognition in isoprenoid glycolipids in Mycobacterium tuberculosis infection
Article Abstract:
It has been possible to define a new class of widely distributed lipid antigens presented by the CD1 system during infection in vivo. T-cell activation by recognition of dolichols provides a mechanism for immune recognition of changes in the level or structure or isoprenoid glycolipids.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Apolipoprotein-mediated pathways of lipid antigen presentation
Article Abstract:
The pathways mediating markedly efficient exogenous lipid antigen delivery by apolipoproteins to achieve T-cell activation is defined. Apolipoprotein E binds lipid antigens and delivers them by receptor-mediated uptake into endosomal compartments containing CD1 in antigen-presenting cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor
Article Abstract:
The structure of a human natural killer T cell receptor (NKT TCR) in complex with CD1d bound to the potent NKT-cell agonist [alpha]-galactosylceramide, the archetypal CD1d-restricted glycolipid is described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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