CaT1 manifests the pore properties of the calcium-release-activated calcium channel
Article Abstract:
Research is presented describing how the protein CaT1, with its six membrane-spanning domains, manifests the pore properties of the calcium-release-activated calcium channel, ICRAC. The CaT1 channel is the same as ICRAC for features including an anomalous mole fraction effect, block by lanthanum, whole-cell current kinetics, and many other features, and this has led researchers to conclude that the ICRAC pore is made up entirely, or in part, of CaT1.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Channelling calcium
Article Abstract:
When the concentration of calcium ions increases inside cells, the ions become vital signals for controlling such processes as muscle contraction, cell development and death, and protein secretion. One mechanism by which calcium ions increase in concentration is capacitative calcium entry, and recent research by Lixia Yue et al may help scientists understand the molecular and cellular mechanism which controls the capacitative calcium entry channel.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Integration hot-spot gets hotter
Article Abstract:
Guanine-nucleotide-binding (G) proteins have been found to regulate voltage-gated Ca(2+). The modulatory pathways that affect the calcium ions are highly diverse, which reflect the wide variety of the ions' physiological functions. New studies by Zamponi et al. and De Waard et al. offer insights into the occurrence of one form of G-protein-mediated inhibition usually found among neuronal Ca(2+) channels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Experimental measurement of the photonic properties of icosahedral quasicrystals. Complete photonic bandgaps in 12-fold symmetric quasicrystals
- Abstracts: Rapid communication: a PCR-RFLP in the coding region of the bovine tumor necrosis factor-alpha locus. Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene
- Abstracts: Central-place foraging continues beyond the nest entrance: The underground performance of leaf-cutting ants. Foraging behavior of Atta cephalotes (leaf-cutting ants): an examination of two predictions for load selection
- Abstracts: Effects of habitat size and patch isolation on reproductive success of the Serpentine Morning Glory. Influence of habitat patchiness on genetic diversity and spatial structure of a serpentine endemic plant
- Abstracts: Hall-effect across a heavy-fermions quantum critical point. The break-up of heavy electrons at a quantum critical point