Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast
Article Abstract:
The interactions of the immunosuppressants FK506 and cyclosporin A with their respective cytosolic receptors, FKBP-12 and cyclophilin, and calcineurin in the inhibition of recovery from alpha-mating factor arrest in yeast are similar to those involved in the inhibition of T-cell activation. In the inhibition of recovery of yeast from alpha-factor arrest, the drug-receptor complexes inhibit the calcineurin. These and other parallels suggest new directions for investigation into the Ca2+/calcineurin-dependent signal transduction pathways in yeast and T cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
The glyoxylate cycle is required for fungal virulence
Article Abstract:
Research describing the significance of the glyoxylate cycle in microbial pathogenesis is presented. In particular fungal infections in immunosuppressed patients caused by Candida albicans are investigated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
SLAM (CDw150) is a cellular receptor for measles virus
Article Abstract:
Research is presented concerning the identification of the signalling lymphocyte-activation molecule CDw150 as a cellular receptor for the Edmonston strain of measles virus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nuclear pore complexes in the organization of silent telomeric chromatin
- Abstracts: A crystal clear view. Water stress inhibits plant photosynthesis by decreasing coupling factor and ATP. Proton-powered turbine of a plant motor
- Abstracts: NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
- Abstracts: Celebrating science: scientists feel passion, but they need to convey it in their writing, too. What if...?
- Abstracts: Hanford nuclear radiation doses assessed. Radiation doses from Ural region. The man who knew doses