Calmodulin supports both inactivation and facilitation of L-type calcium channels
Article Abstract:
Calmodulin is a vital Ca2+ sensor for both inactivation and facilitation. Residues within the consensus calmodulin-binding isoleucine-glutamine (IQ) motif significant for calmodulin binding determine the nature of the modulatory effect. It has also been shown that a putative IQ motif in the cytoplasmic tail of alpha-1C binds to calmodulin and is also significant for the opposing modulatory actions. Mutation of Ile 1624 to alanine inhibits Ca2+-dependent inactivation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A modular switch for spatial [Ca.sup.2+] selectivity in the calmodulin regulation of [Ca.sub.v] channels
Article Abstract:
The development of a modular switch for the spatial [Ca.sup.2+] selectivity in the calmodulin (CaM) regulation of [Ca.sub.v] channels is discussed. The findings show that the spatial [Ca.sup.2+] selectivity can be easily switched by a novel CaM-binding site within the amino terminus of channels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
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Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels
Article Abstract:
Research is presented describing how calcium channels in the brain are affected by calmodulin. In order to simplify the study of molecular mechanisms, researchers studied recombinant P/Q-type calcium channels in HEK293 cells in mammals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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