Cancer body 'must do more for minorities'
Article Abstract:
The US National Cancer Institute (NCI) only spent 1% of its $2.4 billion budget on work with ethnic minorities and the poor, according to a report from the Institute of Medicine (IOM), although this is disputed by the NCI. There are higher incidences and death rates of some cancers amongst ethnic minorities and the poor, and chair of the committee that wrote the report, Alfred Haynes, believes it is important to understand why certain ethnic minorities and the poor are more prone to cancer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A causal role for E-cadherin in the transition from adenoma to carcinoma
Article Abstract:
The loss of E-cadherin expression is found to coincide with the transition from differentiated adenoma to invasive carcinoma in transgenic mice models of Beta-cell carcinogenesis (Rip1Tag2). When Rip1Tag2 mice are intercrossed with transgenic mice that maintain E-cadherin expression in Beta-tumour cells, tumour development at the adenoma stage is arrested, while expression of a dominant-negative type of E-cadherin leads to early invasion and metastasis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Has the smart bomb been defused?
Article Abstract:
Cancer research aims to develop therapies that can kill tumour cells selectively, without affect normal cells. ONYX-015 is a genetically engineered adenovirus which could be useful in treating tumours. However Hall and colleagues have suggested that p53 is required by adenoviruses to kill cells effectively, and proposed that ONYX-015 could kill normal cells. ONYX studies have equated viral replication with cell destruction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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