Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast
Article Abstract:
The control of the cell cycle in the G2/M phase occurs with variations in the extracellular environment that affect cell physiology of a fission yeast. The MAP kinase pathway links the two processes. Yeast with mutations in the spc1 gene has a delay in the G2 phase that increases by an increase in the osmolarity and nutrient limitation in the medium. A lethal interaction of spc1 and cdc25 mutants indicates a role for Spc1 in the promotion of mitosis. Spc1 exhibits similarities to the MAP kinase and is activated during osmotic stress and nutrient limitation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Interaction of Cdc2 and Cdc18 with a fission yeast ORC2-like protein
Article Abstract:
Cdc2 kinase plays a significant role in the regulation of DNA replication in fission yeast. It is shown that Cdc2 interacts with the protein Orp2, which is also a necessary component of DNA replication and with reacts to the rate-controlling replication activator Cdc18. The involvement of Orp2 in the development of a checkpoint signal is evident in the abnormal mitosis undergone by Orp2-deficient cells. Findings indicate that Cdc2 determines DNA replication initiation through its direct participation at chromosomal origins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein
Article Abstract:
A cell-cycle checkpoint is activated by DNA damage, so that mitosis is prevented while DNA repair progresses. Chk1, a protein, enforces the checkpoint by phosphorylating Cdc25, a mitotic inducer. Rad24 is found to control the intracellular distribution of Cdc25, and its elimination results in nuclear accumulation of Cdc25. Rad25 seems to operate as an attachable nuclear-export signal, improving the nuclear export of Cdc25.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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