Cell-to-cell spread of calcium signals mediated by ATP receptors in mast cells
Article Abstract:
Increasing calcium ions (Ca2+) in basophilic leukemia cells can move from cell to cell by using adenosine triphosphate (ATP) as an intermediate. Leukemia cells and mast cells have cell-surface P2-type purinergic receptors that can initiate Ca2+ reactions. ATP can thus be quickly produced to strengthen Ca2+ signals and secretory reactions while antigen-stimulation of basophilic leukemia cells is occurring.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes
Article Abstract:
A potential-initiated mitochondrial Ca2+ uptake in Xenopus laevis oocytes is significant for the regulation of inositol-1,4,5-trisphosphate-mediated Ca2+ release and defines the physiological activity of mitochondria as necessary for intracellular signalling of calcium waves. Ca2+ release is increased by oxidizable substrates that activate mitochondria enhancing Ca2+ wave height and the interwave period.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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ATP joins the fast lane
Article Abstract:
Adenosine triphosphate (ATP) may be a fast neurotransmitter. Two research groups, R.J. Evans and colleagues and Frances A. Edwards and colleagues, succeeded in demonstrating that ATP has a neurological role similar to that of glutamate, acetylcholine and serotonin. This role consists of allowing the signalling between neurons in the central nervous system to occur in no more than a millisecond.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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