Characterization and inhibition of a cholecystokinin-inactivating serine peptidase
Article Abstract:
The human tripeptidyl peptidase II (TPPII) is a neuropeptidase that inactivates cholecystokinin (CCK). TPPII is a serine peptidase with a molecular mass of 135,000 and is irreversibly labeled on sodium dodecy sulphate-polyacrylamide gel electrophoresis. TPPII is present in the brain, liver, testis, kidney and spleen. It is both cytosolic and linked to the synaptonemal membranes. The enzyme is specific for CCK-8 which it breaks up into biologically inactive parts. Blockade of TPPII by butabindide prevents the inactivation of neuronal CCK-8. CCK-responsive neurons express TPPII.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Selective inhibition of cocaine-seeking behavior by a partial dopamine D(sub3) receptor agonist
Article Abstract:
Environmental stimuli associated with the effects of abused drugs, particularly cocaine, may produce craving in abstinent human substance abusers. The first D(sub3)-receptor-selective agonist, BP897 was designed and assessed in vitro and in vivo with mice having disrupted D(sub3)-receptor genes. BP 897 was found to inhibit cocaine-seeking behaviour.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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High constitutive activity of native H3 receptors regulates histamine neurons in brain
Article Abstract:
Research carried out concludes that H3 receptors are present in rat brains and control histaminergic neuron activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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