Clonal selection and learning in the antibody system
Article Abstract:
Antibody-producing B cells and somatically mutated memory cells use cell proliferation along with stringent cellular selection for production and survival of cells of the desired specificity. Antibody-producing B cells generate antibodies of unique specificity in a series of ordered gene rearrangements. Another selection during immune responses produces a series of antibodies through somatic hypermutation. Both the processes use antigen-mediated negative selection to avoid self-reactivity. The unselected cells die most probably by apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice
Article Abstract:
The activation of B-cells by the T-cell-dependent antigens as well as the maturation and selection of the cells into the memory compartment requires the antigen CD19, which is a differentiation antigen in the B-cells. The development of conventional B-cells is not impaired in CD19 deficient mice but mature CD19(super -/-) B cells are unable to bind to T-cells and there is no germinal center formation and maturation of serum antibodies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Burnet's unhappy hybrid
Article Abstract:
Genetic research scientist F.M. Burnet concluded that B lymphocyte cells establish antigen receptor specificity prior to antigen stimulation. Modern genetic research suggests that B lymphocyte cells modify antigen receptor specificity in response to antigen stimulation via somatic hyperpointmutation. Burnet's work concluded that V(D)J recombination in B-cell development was a distinct acceptable possibility.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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