Conformational variations in an infectious protein determine prion strain differences

Article Abstract:

A high efficiency protocol for infecting yeast with the [PSI(super +)] prion using amyloids composed of a recombinant Sup35 fragment (Sup-NM) is reported. The reports establish that Sup-NM adopts an infectious conformation before entering the cell - fulfilling a key prediction of the prion hypothesis- and directly demonstrate that differences in the conformation of the infectious protein determine prion strain variation.

Science & research, Research, Yeast fungi, Yeasts (Fungi)

---

Generation of prion transmission barriers by mutational control of amyloid conformations

Article Abstract:

Point mutations in the protein determinant of yeast prion alter conformational states of amyloid leads to the generation of prion transmission barriers but without affecting amyloid formation. Data indicate that these mutations change amyloid seeding specificity and the transmission barriers selectively disfavour subsets of prion strains.

United States, Analysis, Influence, Gene mutations, Gene mutation, Amyloid beta-protein, Protein conformation

---

Conformational diversity in a yeast prion dictates its seeding specificity

Article Abstract:

Research is presented concerning the use of a yeast prion to investigate the ability of prions, made up of the same polypeptide, to produce different phenotypes when propagated within hosts which are genetically identical.

Genetic aspects, Yeast, Yeast (Food product), Letter to the Editor

Similar abstracts:

• Abstracts: Three key residues form a critical contact network in a protein folding transition state. Simultaneous determination of protein structure and dynamics
• Abstracts: Epigenetic regulation of translation reveals hidden variation to produce complex traits. A yeast prion provides a mechanism for genetic variation and phenotypic diversity
• Abstracts: Interactions of an insecticide with larval density and predation in experimental amphibian communities. Variation in pesticide tolerance of tadpoles among and within species of ranidae and patterns of amphibian decline
• Abstracts: Male disturbance, repeated insemination and sperm competition in the damselfly Coenagrion scitulum (Zygoptera: Coenagrionidae)
• Abstracts: China takes centre stage for liver proteome. Chinese plan pins big hopes on small science. A great leap forward

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.