Control of transcription by Kruppel through interactions with TFIIB and TFIIE-beta
Article Abstract:
Coimmunoprecipitation experiments with the zinc-finger protein Kruppel (Kr) and recombinant initiation factors showed that it can associate with TFIIB and TFIIE-beta. It does not associate with TFIIE alpha and TATA- binding proteins (TBP). The association with TFIIB and TFIIE-beta takes place in the presence of Kr-binding sites which indicates that only DNA-bound Kr is capable of the association.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Dimerization and the control of transcription by Kruppel
Article Abstract:
The Kruppel (KR) monomer is a transcriptional activator. Through sequences located within the C terminus, KR is able to form homodimers. These sequences constitute a functional transcription activator on dimerization in vivo when fused to functional parts of the yeast transcription factor GAL4-5. KR forms a homodimer that functions on the same areas as the activator at higher concentrations.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Activation of posterior gap gene expression in the Drosophila blastoderm
Article Abstract:
Posterior gap gene expression in Drosophila blastoderm is activated through a partly redundant activator system involving a conserved homeodomain protein, caudal. The posterior-to-anterior concentration gradient is formed by caudal after the posterior maternal system allows the gap genes to activate by preventing the activation of the hunchback repressor.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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