Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
Article Abstract:
The conditional paired box gene 5 (Pax5) deletion in mice has allowed mature B cells from peripheral lymphoid organs to differentiate in vivo back to early uncommitted progenitors in the bone marrow, which has rescued T lymphopoiesis in the thymus of T-cell-deficient mice. The complete loss of Pax5 in late B cells has initiated lymphoma development and has disclosed a plasticity of mature peripheral B cells despite their advanced differentiation stage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
LOng-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
Article Abstract:
Cloned Pax5-deficient pro-B cells placed into RAG2-deficient mice were found to give long-term reconstitution of the thymus and form mature T cells expressing alpha/Beta-T-cell receptors. Pax5 is thus implicated in the control of B-lineage commitment, and not immunoglobulin DJ rearrangement or expression of E2A, EBF, lambda5, VpreB, Igalpha and IgBeta.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5
Article Abstract:
The Pax5-gene is expressed in the haematopoietic system solely in the B-lymphoid lineage, although it is not required for in vitro propagation of pro-B cells in the presence of interleukin-7 and stromal cells. Pro-B cells lacking Pax5 are shown to be incapable of in vitro B-cell differentiation until restoration of Pax5 expression.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Termination of asymmetric cell division and differentiation of stomata. Endothelial tubes assemble from intracellular vacuoles in vivo
- Abstracts: Short-range control of cell differentiation in the Arabidopsis root meristem. Cell fate in the Arabidopsis root meristem determined by directional signalling
- Abstracts: The use of path integration to guide route learning in ants. Local and global vectors in desert ant navigation
- Abstracts: Real-time observation of vortex lattices in a superconductor by electron microscopy. Observations of individual vortices trapped along columnar defects in high-temperature superconductors
- Abstracts: Changes in olfactory responsiveness by the domestic chick after early exposure to odorants. Prenatal light exposure affects early feather-pecking behavior in the domestic chick