Coordination of agonist-induced Ca2+ signalling patterns by NAADP in pancreatic acinar cells
Article Abstract:
Research into the possible roles in mammalian cells for the Ca2+-mobilizing molecule nicotinic acid adenine dinucleotide phosphate (NAADP) has studied its impact on Ca2+ signals in pancreatic acinar cells. It was found that only very low concentrations of NAADP are required to induce Ca2+ spiking. This, along with the ability of NAADP to produce complex patterns of Ca2+ signals and the abolition of cholecystokinin signalling when cells are perfused with desensitizing concentrations of NAADP, suggests that NAADP could be a key intracellular mediator of this hormone.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Control of spatial orientation and lifetime of scroll rings in excitable media
Article Abstract:
Structures in the form of rotating spiral waves of excitation can be maintained by excitable media, such as autocatalytic chemical systems and biological tissue. Spiral wave dynamics in two-dimensional systems can be controlled externally, by electrical, optical and thermal fields. Three-dimensional systems have similar dynamics, called scroll waves. A particular class of scroll waves, known as scroll rings, are shown to respond to an external temperature gradient field. Details of the study are presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Role of Ca2 plus /K plus ion exchange in intracellular storage and release of Ca2 plus
Article Abstract:
Changes in the concentration of cytosolic Ca2 play an important part in the sending of intracellular messages in cells. There is insufficient understanding of how Ca2 is stored in cells and how it is released. When stored Ca2 is released rapidly it needs large concentration gradients that were thought to come from low-affinity buffering. Research shows a low level of resting Ca2 that is luminal-free within the mucin granules and the endoplasmic reticulum.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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