Corneal avascularity is due to soluble VEGF receptor-1
Article Abstract:
A study shows that the cornea expresses soluble vascular endothelial growth factor (VEGF) receptor-1 (sVEGFR-1 or sflt-1) and that suppression of this endogenous VEGF-A trap by neutralizing antibodies, RNA interference or Cre-lox-mediated gene disruption abolishes corneal avascularity in mice. The sflt-1 is necessary for preserving the avascular ambit of the cornea and it can be used in treating neovascular diseases.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Local translation of RhoA regulates growth cone collapse
Article Abstract:
Neuronal development requires a highly coordinated regulation of the cytoskeleton with the developing axon. This regulation manifests in axonal branching, turning and pathfinding, presynaptic differentiation and growth come collapse and extension.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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