Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution
Article Abstract:
SNARE proteins and their complexes take part in the fusion of vesicles with their target membranes, but their overall organization and structural details are not well known. The X-ray crystal structure of a core synaptic fusion compound containing syntaxin-1A synaptobrevin-II and SAP-25B is reported to reveal a highly twisted and parallel four-helix bundle. The centre of the synaptic fusion complex contains a conserved leucine-zipperionic layer, within which there are glutamine residues. The characteristics may be significant for membrane fusion.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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SNAREs line up in new environment
Article Abstract:
New research has provided useful information about the inner workings of SNARE proteins and their impact on membranes. It has been possible to reconstitute SNAREs into artificial membranes, permitting these proteins to be investigated in a defined environment. It has been shown in a purified system that SNAREs can interconnect, and perhaps fuse, membranes. This complements results obtained using the complex biological membranes of yeast vacuole-precursor vesicles.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Real-time measurement of transmitter release from single synaptic vesicles
Article Abstract:
A study conducted on the release of neurotransmitter serotonin from neurons of the leech reveals that properties such as charge, amplitude, kinetics are due to exocytosis of small clear vesicles (SSV) and large dense-core vesicles (LDCV) present in the cells. Carbon fibers were used as electrochemical detectors. Two types of signals were observed, corresponding to the two types of vesicles. Exocytosis of SSV is faster than LDVC.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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