Calcium signalling in the guidance of nerve growth by netrin-1
Article Abstract:
It has been established that Ca2+ influx and Ca2+-induced Ca2+ release (CICR) play a role in mediating growth-cone guidance induced by the guidance molecule netrin-1. The netrin-1 induced turning response depends on Ca2+ influx through plasma membrane Ca2+ channels and on Ca2+-induced Ca2+ release from cytoplasmic stores. This research indicates the significance of the precise profile of Ca2+ gradients in establishing the turning response of the growth cone.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Cyclic AMP/GMP-dependent modulation of Ca (super)2+ channels sets the polarity of nerve growth-cone turning
Article Abstract:
Research has been conducted on cyclic AMP and GMP. The authors demonstrate that cyclic AMP to cyclic GMP activity ratio affects netrin-1-induced axon guidance polarity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1
Article Abstract:
Extracellular matrix (ECM) molecules modulate the response of growing axons to secreted guidance cues, as well as acting in substrate-mediated adhesion. It has been established that, in Xenopus, laminin-1 from the ECM converts netrin-mediated attraction into repulsion. The netrin-1-induced rise in cyclic AMP could assist in promoting a polymerization-based attractive response, while laminin-1 could encourage a repulsive response by favouring netrin-1-mediated depolymerization.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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