Defective mismatch binding and a tolerant phenotype in cells tolerant to DNA damage
Article Abstract:
The effect of the resistance to alkylating agents such as N-methyl-N-nitrosourea or N-methyl-N'-nitro-N-nitrosoguanine combined with the loss of the ability for mismatch correction were investigated. Previous studies of Escherichia coli have shown that mismatch correction helps maintain genomic fidelity by removing misincorporated bases, and loss of mismatch correction confers a mutator phenotype. The results using human and hamster cell lines showed that resistance to alkylating agents combined with the loss of mismatch repair ability also confers a mutator phenotype on these cell types.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA
Article Abstract:
MutS protein, a member of the ABC ATPase family, is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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The crystal structure of DNA mismatch repair protein MutS binding to a G.T. mismatch
Article Abstract:
DNA mismatch repair is researched.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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