Degenerin similarities
Article Abstract:
Recent research has identified the alpha-rENaC gene whose product causes amiloride sensitivity in Xenopus oocytes. This gene has marked similarity to the deg-1 and mec-4 genes of Caenorhabditis elegans. All three genes exhibit similarity over their entire length indicating they are of the same genetic family. The ability of alpha-rENaC to stimulate amiloride-sensitivity suggests that perhaps deg-l, mec-4 and the newly discovered mec-10 may be similarly involved in a sodium-channel complex and part of a mechanotransducing channel.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
Article Abstract:
It appears that Caenorhabditis elegans uses CTL-1 to deal with oxidative stress in the cytosol, where it could work with a superoxide dismutase. Counteracting cytosolic oxidative stress may permit animals to undergo long periods of pre-reproductive dormancy as dauer larvae. The cytosolic catalase could be a quite new acquisition for C. elegans and other nematodes, but an alternative view is that cytosolic catalases could be quite general and used especially during periods of nutrient reduction.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A stomatin-like protein necessary for mechanosensation in C. elegans
Article Abstract:
The stomatin-like mec-2 protein (MEC-2) connects the mechanosensory transduction channels and the microtubule cytoskeleton of the touch receptor neurons, in Caenorhabditis elegans. This connection causes a mechanosensation resulting in channel opening due to microtubule displacement. The region between the hydrophobic domain and the carbonyl end of the human stomatin resembles the MEC-2. The touch receptor axons contain MEC-2-Lac Z fusions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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