Parental-origin-specific epigenetic modification of the mouse H19 gene
Article Abstract:
Parental imprinting in the expression of the H19 gene in mouse embryos was examined. In normal embryos, the H190 gene expresses a developmentally regulated product of unknown function. The gene lies on chromosome 7 and is susceptible to trancriptional regulation by parental imprinting, causing the expression of the maternally inherited gene and suppression of the paternally inherited gene. The study protocol comparison of CpG methylation and nuclease sensitivity of chromatin in MatDi7 embryos with those of normal littermates. The results that the H19 promoter gene region is hypermethylated only in the paternal allele.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
Article Abstract:
Mutations in the src and fyn genes were introduced into csk(super-) mutant background to study the role of activated Src family kinases in the csk(super -1) phenotype. The research revealed that src is partly epistatic to the csk gene while fyn is possibly redundant or unnecessary. The influence of the src on cortactin, tensin and paxillin hyperphosphorylation, focal adhesion kinase and the normal distribution of cortactin is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A stop-codon mutation in the BRI gene associated with familial British dementia. Pathways to neuronal injury and apoptosis in HIV-associated dementia
- Abstracts: Determination of the fold of the core protein of hepatitis B virus by electron cryomicroscopy. Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
- Abstracts: Gilbert's Potoroo: Australia's rarest mammal clings to existence on the slopes of Mount Gardner in Western Australia
- Abstracts: Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia. Cell-free activation of a DNA-binding protein by epidermal growth factor