Dissociating prefrontal and hippocampal function in episodic memory encoding
Article Abstract:
There are functionally dissociable roles for the left medial temporal cortex and left prefrontal cortex during encoding of auditory-verbal material, according to an experiment involving learning category-exemplar word pairs. This functional and anatomical dissociation indicates that anatomically distinct parts of the brain have differential sensitivities to stimulus parameters. Prefrontal activation was found to reflect a relative emphasis on associative semantic processing required to establish and maintain new semantic linkages against a background of already established linkages.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Charting the circuits
Article Abstract:
Positron emission tomography (PET) imaging of the regional flow of blood in the brains is useful to understand the causes of schizophrenia. Application of PET reveals that the levels of dopamine-receptor density in the striatum are either high or normal in the dopamine-sensitive schizophrenics. The insignia symptom of schizophrenia, hallucination, can be identified by analyzing the regions in the brain with increased blood flow. The cingulate gyrus, and limbic and paralimbic structures of the patients can be examined by PET.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Activation of medial temporal structures during episodic memory retrieval
Article Abstract:
Medial temporal activity is associated with the success of episodic retrieval of verbal information. In a study, positron emission tomography was used to analyze cerebral blood flow related to verbal episodic retrieval. The correlations between retrieval and blood flow in the left medial temporal structures were high in normal human beings. Multivariate analysis indicates that regions in the left variate medial temporal lobe are major components of a brain region that differentiate a high-retrieval condition from a low one.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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