Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients
Article Abstract:
Studies conducted on the Xenopus embryo show that in the developing spinal neurons Ca2+ transients are formed spontaneously and neuronal differentiation is affected by stopping Ca2+ influx. Ca2+ spikes and waves are encoded in different frequencies and influence different events. The spikes control expression of the neurotransmitter and maturation of the channels while the waves control extension of the neurites. The Ca2+ transients activate protein kinase and influence transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Electrical activity in early neuronal development
Article Abstract:
The newly discovered function of electrical activity that plays an essential role in early development of the nervous system that follows neural induction and precedes synapse formation is presented. The findings suggest that activity has similar roles in the incorporation of newly born neurons in the adult nervous system and is required at all developmental stages as a necessary partner with genetic programs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Activity-dependent homeostatic specification of transmitter expression in embryonic neurons
Article Abstract:
The role of electrical activity and Ca2+ influx in the specification of neurotransmitter expression in the developing spinal cord of Xenopus laevis embryos is examined. The alteration of expression of acetylcholine and glutamate without affecting the markers of neuronal identity is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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