RecA acts in trans to allow replication of damaged DNA by DNA polymerase V
Article Abstract:
The role of pol V in SOS DNA damage induced mutagenesis is analyzed and whether transactivation is required for pol V activity when the [beta]-prcoessivity clamp is included in the reaction is determined. It is suggested that trans-stimulation of pol V by RecA bound to SSDNA reflects a distinctive regulatory mechanism of mutation that resolves the paradox of RecA filaments assembled in cis on a damaged template strand obstructing translesion DNA synthesis despite the absolute requirement of RecA for SOS mutagenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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The structural basis of yeast prion strain variants
Article Abstract:
Several methodologies are utilized to analyze the various differences between different strain conformations of yeast prion. The results show that prion strains have large-scale conformational differences that alter their physiological impact.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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