Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Article Abstract:
A study reveals that delta-like4 (Dll4)-Notch1 signalling has regulated the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina. The results have indicated that Dll4-Notch1 signalling between endothelial cells within the angiogenic sprout has restricted the tip-cell formation in response to vascular endothelial growth factor and they can be used as pharmacological regulators of angiogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Article Abstract:
Bone marrow-derived haematopoietic progenitor cells that express vascular endothelial growth factor receptor 1 (VEGFR1) appear to home in on tumour-specific pre-metastatic sites and VEGFR1(super plus) form cellular clusters before the arrival of tumour cells. These cells express VLA-4 and tumour -specific growth factors upregulate fibronectin-a VLA-4 ligand in resident fibroblast, providing a permissive niche for incoming tumour cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Inhibition of Dll4 signalling inhibits tumor growth by deregulating angiogenesis
Article Abstract:
A study shows that the Dll4-mediated Notch signaling has a unique role in regulating endothelial cell proliferation and differentiation. It is also revealed the Notch signaling is crucial during active vascularization, but less important for normal vessel maintenance.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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