Embryonic lethality and radiation hypersensitivity mediated by RAD51 in mice lacking Brca2
Article Abstract:
People with mutations in the BRCA1 or BRCA2 genes have a dominant predisposition to cancer, with inherited mutations in BRCA1 causing breast and ovarian cancer and in BRCA2 mostly breast cancer. Recent observations of a link between BRCA1 and HsRad51, give some insight into the BRCA1 function. The function of BRCA2 in mouse cell proliferation and possible DNA repair is described, concentrating on the developmental arrest in BRCA2-deficient embryos, and their radiation sensitivity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex
Article Abstract:
The carboxy terminus of human Nijmegen breakage syndrome hypomorphic (NBS1) is not sufficient for the MRE11 and the ataxiatelangiectasia mutated (ATM) kinase function. The ATM signalling can be mediated by distinct molecular determinants within the MRE11 complex and the different outcomes of the ATM-MRE11-complex DNA damage response might be governed by distinct molecular interactions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
Article Abstract:
It has been possible to link the ATM gene and the p95/nbs1 gene in a common signalling pathway. This explains phenotypic similarities between the rare diseases ataxia-telangiectasia and Nijmegen breakage syndrome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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