Renal agenesis and the absence of enteric neurons in mice lacking GDNF
Article Abstract:
Mice lacking the exon coding glial-cell-line-derived neurotrophic factor (GDNF) show agenesis of the kidney, apoptosis of mesenchymal-blastemal cells, lack of enteric neurons and defective innervation of the gastrointestine motility. The absence of kidney development is due to lack of ureteric bud formation and invasion of the metanephric mesenchyme. The absence of enteric neurons probably causes pyloric stenosis and duodenum dilation. The development of dopaminergic neurons, gonads, adrenal glands, limbs and brain is normal. The mutation is lethal and all mice die within the first postnatal day.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Renal and neuronal abnormalities in mice lacking GDNF
Article Abstract:
Mice homozygous for a null glial-cell-line-derived neurotrophic factor (GDNF) allele exhibit the absence of kidneys, ureters and enteric nervous system (ENS). The mutants show defects in the sympathetic and nodose neurons, and dorsal root ganglion. The basal forebrain, cerebellum, striatum, neocortex, hippocampus, and the dopaminergic, catecholaminergic and noradrenergic neurons are normal. This indicates that GDNF is necessary for the development of ENS, kidney, and sympathetic and sensory neurons. The homozygous mice die within two days of birth while the heterozygous mice are normal in size.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Defects in enteric innervation and kidney development in mice lacking GDNF
Article Abstract:
Mice containing an inactive glial-cell-line-derived neurotrophic factor (GDNF) gene show defects in kidneys, gastrointestinal enteric innervation and peristalsis. The mutant mice show unilateral abnormally shaped kidneys, cortical cysts, unilateral renal agenesis and bilateral kidney dysgenesis. The homozygous mutants lack myenteric plexus neurons and enteric parasympathetic cholinergic ganglion cells. However, other urogenital organs, dopamine and cortical cholinergic neurons, and brain-stem motor nuclei are normal in the mutant mice.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
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