Emergence of vancomycin tolerance in Streptococcus pneumoniae
Article Abstract:
Streptococcus pneumoniae is the common cause of sepsis in meningitis, and there are many multiple-antibiotic resistant strains. Emergence of antibiotic vancomycin resistance would be disastrous. The loss of function of the VncS histidine kinase of a sensor regulator system in S. pneumoniae was found to produce tolerance to vancomycin and other antibiotics. The results show that signal transduction is essential for the bactericidal activity of antibiotics. Experimental meningitis caused by the vncS mutant did not respond to vancomycin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
A triclosan-resistant bacterial enzyme
Article Abstract:
Research is presented concerning the bacterial fatty-acid biosynthesis of Streptococcus pneumoniae. The development of a FabK-specific inhibitor which can inhibit fatty-acid biosynthesis is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
How wild are wild mammals?
Article Abstract:
The antibiotic resistance of wild moose, deer and vole is tested to discover the effect of human activities on resistance frequencies.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Evidence for basal marine ice in the Filchner-Ronne ice shelf. Comparison of deep ice cores
- Abstracts: Maintenance of functional equivalence during paralogous Hox gene evolution. Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11
- Abstracts: Gatekeepers of recombination. Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae
- Abstracts: Identification of molecular-cloud material in interplanetary dust particles. The extraterrestrial wedding ring
- Abstracts: Excited-state enhancement of optical nonlinearities in linear conjugated molecules. Gigantic optical nonlinearity in one-dimensional Mott-Hubbard insulators