Epithelial NEMO links innate immunity to chronic intestinal inflammation
Article Abstract:
A study was conducted to show that the transcription factor NF-[kappa]B, a master regulator of pro-inflammatory responses, functions in gut epithelial cells to control epithelial integrity and the interaction between the mucosal immune system and gut microflora. The results identified NF-[kappa]B signaling in the gut epithelium as a critical regulator of epithelial integrity and intestinal immune homeostasis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity
Article Abstract:
Helicobacter pylori CagA have interacted with PAR1/MARK kinase, which plays a major role in epithelial cell polarity. Results show that PAR1 is a key target of Helicobacter pylori CagA in the disorganization of gastric epithelial architecture underlying mucosal damage, inflammation and carcinogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Developmental biology: A hairy situation
Article Abstract:
A critical step in hair-follicle, sweat gland or mammary gland development is the rearrangement of epithelial stem cells. Includes diagram, and discusses the importance of E-cadherin, which mediates cell-cll contacts.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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