Evidence for a selectively favourable reduction in the mutation rate of the X chromosome
Article Abstract:
An examination of 33 X-linked genes that have been sequenced in both mouse and rat and a comparison of their rate of evolution against 238 autosomal genes revealed a significant difference between the mutation rate on rodent X chromosomes and the non-sex-related chromosomes. Such difference is too substantial to be accounted for by a higher mutation rate in males or by stronger purifying selection against slightly deleterious mutations on the X. The closest explanation is that rodents have a lower mutation rate on the X chromosom than on autosomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Sex and the X
Article Abstract:
Research examining the relevance of the number and location of genes in the constitution of genomes specific to the two sexes is presented. Particular attention is given to spermatogenetic analysis of genome constitution. It is emphasized that sex chromosomes are directly related to sex-specific genes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
The proteins of linked genes evolve at similar rates
Article Abstract:
A new predictor of a protein's rate of evolution is reported.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Evidence for social facilitation of preening in the common tern. Host choice and success of gulls and terns kleptoparasitizing brown pelicans
- Abstracts: Evidence for evolutionary conservation of sex-determining genes. MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
- Abstracts: Evidence for enhanced mixing over rough topography in the abyssal ocean. Volcanic growth faults and the origin of Pacific abyssal hills
- Abstracts: Human cerebellar activity reflecting an acquired internal model of a new tool. Internal model visualized
- Abstracts: False perception of motion in a patient who cannot compensate for eye movements. Encoding of movement time by populations of cerebellar Purkinje cells