Expression of a potassium current in inner hair cells during development of hearing in mice

Article Abstract:

Little is known about the way membrane currents of the inner and outer hair cells (IHCs and OHCs) develop. Whole cell voltage clamp has been used to study time and voltage-dependent conductances of IHC, the cells that signal the reception of sound to the brain. Outward membrane currents of IHCs increase slowly before P11-P12, acquiring and additional fast component by P13. The results show that the developmental change in the expression of K- channels lead to the biophysical maturation of sensory cells within the mammalian ear.

Research, Physiological aspects, Hearing, Ear

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Translational control perks up

Article Abstract:

Cells are able to respond to threats, and stress responses can be linked to protein synthesis and folding. In Saccharomyces cerevisiae, these are controlled by GCN2 and Ire1 genes. Harding and colleagues have described a new mammalian gene which has features from both of the yeast genes, and both Harding and colleagues and Shi and colleagues have cloned the gene, RNA-dependent protein kinase PERK.

Proteins, Protein synthesis

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