Arterial hardening in mice
Article Abstract:
The risk factors for human atherosclerosis are well known, but with one exception until now its etiology has been difficult to establish. A study using transgenic mice expressing human apolipoprotein(a) shows that on high-fat diets those mice develop atherosclerosis. Other studies that knock out certain genes encoding components involved in lipid transport in the blood have had similar results. The transgenic mice developed a form of atheroma similar to the human disease in which lipid-rich fibrous plaques are developed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Good cholesterol news
Article Abstract:
Three groups have studied patients with Tangier disease, a rare, recessive disorder, characterized by the reduced efflux of cholesterol from cells. They found that the disease is due to defects in an ATP-binding-cassette (ABC) transporter gene encoding the cholesterol-efflux regulatory protein (CERP). This discovery provides information on high-density lipoprotein metabolism and opportunities for the prevention of heart attacks and drug discovery.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Localization of the malignant hyperthermia susceptibility locus to chromosome 19q12-13.2. Cyclin D control of growth rate in plants
- Abstracts: Invariant chain influences the immunological recognition of MHC class II molecules. Presentation of viral antigen controlled by a gene in the major histocompatibility complex
- Abstracts: Role of abortive retroviral infection of neurons in the spongiform CNS degeneration. Long-range cis effects of ectopic X-inactivation centres on a mouse autosome
- Abstracts: The alpha 1 domain of the HLA-DR molecule is essential for high-affinity binding of the toxic shock syndrome toxin-1
- Abstracts: Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse. Localization of dystrophin to postsynaptic regions of central nervous system cortical neurons