Signal sequences stop killer cells
Article Abstract:
Signal sequences in immunology were perceived as somewhat inert, but this view has changed with a finding that the have a function in immune recognition. The immune system is able to discriminate between self and non-self, in order for the body's own tissues not to be destroyed. Braud et al and Borrego et al have studied immune recognition for class 1 molecules of a family called the major histocompatibility complex. Signal sequences of other proteins may be involved in cellular regulation in a similar way.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Antigen presentation mediated by recycling of surface HLA-DR molecules
Article Abstract:
The HLA-DR molecules undergo a vigorous internalization and recycling on a human B-cell and transfected human fibroblasts. Recycling of the surface HLA-DR molecules correlates with the depiction of immunodominant epitopes in the haemagglutinin protein of influenza virus and in myelin basis protein. The internalization of HLA-DR molecules is avoided when either one of the alpha or beta cytoplasmic tails is truncated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The gain of three mitochondrial introns identifies liverworts as the earliest land plants. Introns gain ground
- Abstracts: The orbital evolution of the asteroid Eros and implications for collision with the Earth. Efficient delivery of meteorites to the Earth from a wide range of asteroid parent bodies
- Abstracts: The physiology of the planet. Chill taken out of the tropics. What drives climate?
- Abstracts: Biochemical evidence that patched is the hedgehog receptor. Lunatic fringe is an essential mediator of somite segmentation and patterning
- Abstracts: Functions of the colour-opponent and broad-band channels of the visual system. Vision in blind mole rats