Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

Article Abstract:

CXCR4, a chemokine receptor, is expressed in cells of the immune and central nervous systems, and can control migration of resting leukocytes and haematopoietic progenitors. Mice lacking CXCR4 were found to show haematopoietic and cardiac defects the same as those of SDF-1-deficient mice, suggesting that it may be the only receptor for SDf-1. This is thought to be the first demonstration of G-protein-coupled chemokine receptor involvement in neuronal cell migration and patterning in the central nervous system.

Observations, Central nervous system, Leukocytes, White blood cells, Cerebellum

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Natural resistance to HIV?

Article Abstract:

A mutation in the CC-chemokine receptor 5 (CCR-5) prevents HIV infection despite repeated exposure to the infection. Homozygous mutants of the gene are found in HIV resistant people. HIV-infected individuals have a lower frequency of heterozygous CCR-5 mutants. This indicates a partial protection from HIV infection in individuals with a single mutant gene. Individuals without functional CCR-5 are immunologically well.

Reports, Causes of, HIV infection, HIV infections, Mutation (Biology), Mutation, Natural immunity

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Expression cloning of new receptors used by simian and human immunodeficiency viruses

Article Abstract:

Several types of chemokine-receptors together with CD4, act as receptors for entry of human immunodeficiency virus type I into cells. Infection with some strains of simian immunodeficiency virus (SIV) is mediated by CCR5. An expression cloning strategy is used to identify SIV receptors, isolating genes in the seven-transmembrane G-protein, possibly providing an insight into viral transmission.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Medical Research, HIV (Viruses), HIV, Cell receptors, Simian immunodeficiency virus

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