In situ structure of the complete Treponema primitia flagellar motor
Article Abstract:
Electron cryotomography is used to study the in situ structure of the complete flagellar motor from the spirochaete Treponema primitia, which reveals that the stator assembly possesses 16-fold symmetry and is connected directly to the rotor, C ring and a novel P-ring-like structure. The unusually large size of the motor suggests mechanisms for increasing torque and key functional interactions are believed to occur directly above the C ring, where the carboxyl-terminal and middle domains of the FliG molecules are placed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Flagellar motility is required for the viability of the bloodstream trypanosome
Article Abstract:
A detailed proteomic analysis of the trypanosome flagellum is presented. RNAi-mediated ablation of various proteins identified in the trypanosome flagellar proteome leads to a rapid and marked failure of cytokinesis in bloodstream-form trypanosomes, suggesting that impairment of flagellar function may provide a method of disease control.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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